Publications by authors named "A Redwood"
Article Synopsis
- Spillover from wild animals threatens human health, with few successful global solutions, one of which is the use of oral vaccines for rabies in certain regions.
- There's interest in developing 'transmissible' vaccines that can spread immunity among wildlife, but they raise environmental concerns due to potential release of genetically modified viruses.
- The study proposes a method to control the stability of these vaccines' genetic material, allowing for better management and fine-tuning of their lifespan in wild animal populations through specific genetic adjustments.
Background: Anti-tumor CD8 T cells are important for immunity but can become 'exhausted' and hence ineffective. Tumor-infiltrating exhausted CD8 T cells include less differentiated stem-like exhausted T (Tex) cells and terminally exhausted T (Tex) cells. Both subsets have been proposed as prognostic biomarkers in cancer patients.
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- Cancer immunogenomics combines the study of genes and the immune system to learn more about cancer.
- New technologies allow scientists to look at cancer cells closely and find important changes that could help treat patients.
- The review talks about different computer methods used to analyze cancer data and how to choose the right tool to help doctors improve cancer treatments for patients.
Article Synopsis
- Researchers focused on cytomegaloviruses (CMVs) in Natal multimammate mice, a species found in sub-Saharan Africa and linked to zoonotic diseases like Lassa virus (LASV).
- They isolated infectious CMVs from these mice and sequenced multiple genomes, identifying three distinct CMV types (MnatCMV1, MnatCMV2, and MnatCMV3) and discovering cases of coinfection.
- The findings help understand CMV diversity and are aimed at developing a vaccine based on MnatCMVs to combat LASV in its animal reservoir.
Article Synopsis
- Patient-derived xenograft (PDX) models of breast cancer offer a powerful method for drug testing and discovering biomarkers, especially in triple-negative breast cancer (TNBC).
- The research involved creating PDX models from breast cancer patients before and after neoadjuvant chemotherapy, resulting in 62 successful models from a total of 269 samples, with better success rates from treatment-resistant tumors.
- A predictive model for PDX engraftment was established, focusing on key patient tumor characteristics, and these PDX models are now a valuable resource for advancing treatment strategies in TNBC.