Publications by authors named "A Recke"
Background And Objectives: Patients with rare diseases like hereditary angioedema (HAE) are usually referred to an angioedema center to ensure guideline-compliant and experience-based therapy. Even though there are established guidelines and several approved therapeutics, there are still open questions and situations in the daily care of HAE patients, where an exchange between centers is needed.
Materials And Methods: A survey was conducted among physicians from German angioedema centers regarding challenges and issues in everyday HAE treatment.
Article Synopsis
- A balanced immune system is crucial for defending against infections and preventing autoimmune diseases; an ineffective response allows infections to thrive, while uncontrolled activation can cause inflammatory disorders.
- Researchers screened 1200 small molecules to find drugs that can modify immune cell functions, focusing on T cells, B cells, and polymorphonuclear leukocytes (PMNs) for chronic inflammatory diseases.
- They identified candidate drugs like pyrvinium pamoate, which effectively suppressed B cell activation and slowed down an autoimmune condition, and studied mechanisms in gene-deleted mice to further understand how these actions occur, paving the way for potential drug repurposing to manage immune responses.
Article Synopsis
- The study investigates the relationship between Familial Mediterranean fever (FMF), a severe inflammatory condition, and the risk of cancer development compared to other diseases like fibromyalgia, Still's disease, and Behçet's disease.
- Results show that FMF patients have a significantly lower risk for malignancies compared to fibromyalgia patients, with a risk ratio (RR) of 0.26; however, this risk is less clear when comparing with the other conditions.
- Factors influencing cancer risk in FMF patients include age at onset and diagnosis, frequency of disease attacks, and treatment with specific biotechnological agents.
Background: Bullous pemphigoid (BP), the most common subepidermal autoimmune blistering disease, is classically defined by the presence of IgG autoantibodies directed against the hemidesmosomal proteins BP180 (type XVII collagen) and BP230 and the predominance of skin lesions. Several studies have addressed the role of anti-BP180 IgE in patients and experimental models, while data on anti-BP230 IgE are scarce.
Objective: To assess anti-BP230 IgE level by ELISA in BP sera and to correlate it with disease severity and clinical characteristics.
Background: EU Commission Regulation 2017/1410 prohibits using atranol and chloroatranol, the main allergens in Evernia prunastri (oakmoss), and hydroxyisohexyl 3-cyclohexene carboxaldehyde (HICC) in cosmetic products. Oakmoss absolute is contained in fragrance mix (FM) I and HICC in FM II which are patch tested as screening mixtures in the baseline series.
Objective: To describe the time trends of reaction frequencies to both FMs as well as to their components in FM-positive patients.