Publications by authors named "A Ray Pentecost"
Article Synopsis
- A significant portion (82%) of preterm births occur in the moderate to late category, and these infants are often treated like full-term babies despite their immaturity, leading to higher health risks.
- The study investigated how different caregiving methods (single vs. clustered care) affect stress and hypoxemia markers in infants born between 32 and 36 6/7 weeks’ gestation.
- Findings indicated that clustered caregiving increased stress markers (like oxygen saturation and heart rate) more than when procedures were done individually, highlighting the need for further research to find optimal care practices for these vulnerable infants.
We previously demonstrated that octadecylamine-functionalized nanodiamond (ND-ODA) and dexamethasone (Dex)-adsorbed ND-ODA (ND-ODA-Dex) promoted anti-inflammatory and pro-regenerative behavior in human macrophages . In this study, we performed a pilot study to investigate if these immunomodulatory effects translate when used as a treatment for rheumatoid arthritis in mice. Following local injection in limbs of mice with collagen type II-induced arthritis, microcomputed tomography showed that mice treated with a low dose of ND-ODA and ND-ODA-Dex did not experience bone loss to the levels observed in non-treated arthritic controls.
View Article and Find Full Text PDFChronic inflammatory disorders such as rheumatoid arthritis are characterized by excessive pro-inflammatory or "M1" activation of macrophages, the primary cells of the innate immune system. Current treatments include delivery of glucocorticoids (e.g.
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