Dysregulation of T-cell development in adrenal glucocorticoid-deprived rats.

A number of different experimental approaches have been used to elucidate the impact of basal levels of adrenal gland-derived glucocorticoids (GCs) on T cell development, and thereby T cell-mediated immune responses. However, the relevance of the adrenal GCs to T cell development is still far from clear. This study was undertaken to explore the relevance of basal levels of GCs to T cell differentiation/maturation.

Effect of unilateral and bilateral lesions of caudate-putamen on immune response in the rat.

In the present study we investigated the effect of selectivity destroyed dopaminergic neurons of the caudate-putamen (CP) on immune reactivity in the rat. Unilateral and bilateral lesioning of CP was performed by one direct stereotaxic injection of 6-hydroxydopamine solution. Sham-lesioned and intact rats served as controls.

Beta-adrenoceptor blockade ameliorates the clinical course of experimental allergic encephalomyelitis and diminishes its aggravation in adrenalectomized rats.

As glucocorticoids influence both catecholamine synthesis and adrenoceptor expression by immune cells, the current study was undertaken to distinguish their direct effects on the development of experimental allergic encephalomyelitis from those induced by alteration of catecholamine signaling. We examined the influence of 16-day-long beta-adrenoceptor blockade with propranolol (0.40 mg/100 g body weight/day, s.

Thymopoiesis following chronic blockade of beta-adrenoceptors.

The present study was undertaken in order to further clarify putative role of the adrenergic innervation in the regulation of the intrathymic T-cell maturation. For this purpose adult male DA rats were subjected to either 4-day- or 16-day-long propranolol treatment (0.40 mg propranolol/100 g/day, s.

Effects of beta-adrenoceptor blockade on the phenotypic characteristics of thymocytes and peripheral blood lymphocytes.

The study revealed that beta-adrenoceptor blockade with propranolol (0.40 mg/100 g/day, s.c.