Mental health of young adults pursuing higher education in Tier-1 cities of India: A cross-sectional study.

India, with its vast youth population, grapples with significant mental health issues among young adults in higher education, due to factors such as academic pressure, social isolation, stigma, economic uncertainty, screen time, sedentary lifestyles, and pandemic-related stresses. Though the issue has garnered attention, there's a gap in post-pandemic mental health research for Indian students. This study aims to address this by investigating anxiety, depression, and overall mental well-being among students aged 18-29 in higher educational institutions across eight major Indian cities, categorized by gender, zone, city, and institution type.

Paired primary-metastasis patient-derived organoids and mouse models identify phenotypic evolution and druggable dependencies of peritoneal metastasis from appendiceal cancer.

Peritoneal carcinomatosis is a common yet deadly manifestation of gastrointestinal cancers, with few effective treatments. To identify targetable determinants of peritoneal metastasis, we focused on appendiceal adenocarcinoma (AC), a gastrointestinal cancer that metastasizes almost exclusively to the peritoneum. Current treatments are extrapolated from colorectal cancer (CRC), yet AC has distinct genomic alterations, mucinous morphology and peritoneum restricted metastatic pattern.

Renal Oncocytoma Treated With Stereotactic Body Radiation Therapy in a Patient With Prior Pancoast Tumor.

A renal oncocytoma is a benign tumor of the kidney, typically treated surgically or via ablation therapy, while a Pancoast tumor is a rare tumor of the lung apex, most often non-small cell lung cancer (NSCLC), usually managed with neoadjuvant chemoradiation followed by surgery. In this report, we discuss the diagnosis and management of a 72-year-old man who developed a renal oncocytoma and a recurrent Pancoast tumor. At the time of our patient's treatment for his renal oncocytoma, thermal and radiofrequency ablation were not frequently employed, and active surveillance was also not the standard of care.

Cyclodextrin modified biocompatible Chitosan-Cinnamaldehyde Schiff base hydrogels: Their antibacterial, antioxidant, and drug delivery potential.

Chitosan (CS)-based hydrogels are promising platforms for drug delivery owing to their biocompatibility, biodegradability, and functional versatility. However, pure CS Schiff base hydrogels lack mechanical strength and rely on toxic cross-linkers, necessitating bio-safe alternatives viz. Cinnamaldehyde (CA).

Mixed-Layered Glycodendrimer Probe for Imaging Inflammation at Surgical Site Infections.

Surgical site infections (SSIs) remain the most common cause for readmission following surgery and are associated with significant medical comorbidities. Distinguishing between inflammation and early infection postsurgery is a critical challenge for clinicians. Intraoperative surgical debridement of infectious tissues relies heavily on the surgeon's experience, risking error due to difficulty in distinguishing infection from inflammation.