A Novel In Vitro Model of the Bone Marrow Microenvironment in Acute Myeloid Leukemia Identifies CD44 and Focal Adhesion Kinase as Therapeutic Targets to Reverse Cell Adhesion-Mediated Drug Resistance.

Background/objectives: Acute myeloid leukemia (AML) is an aggressive neoplasm. Although most patients respond to induction therapy, they commonly relapse due to recurrent disease in the bone marrow microenvironment (BMME). So, the disruption of the BMME, releasing tumor cells into the peripheral circulation, has therapeutic potential.

Exploration of Bogdanov-Takens and Hopf bifurcation through coupling of nonlinear recovery with multiple reinfections of COVID-19.

This study introduces a five-compartment model to account for the impacts of vaccination-induced recovery and nonlinear treatment rates in settings with limited hospital capacity. To reflect real-world scenarios, the model incorporates multiple reinfections in both vaccinated and recovered groups. It reveals a range of dynamics, including a disease-free equilibrium and up to six endemic equilibria.

Using a Social Network Approach to Characterize Oral Health Behavior Social Support Among Mexican-Origin Young Adults.

Using a social network approach, we characterize who Mexican-origin young adults perceive as social support sources for oral health behaviors and provide additional validity evidence for Oral Health Behavior Social Support Scales (OHBSS). From April to September 2022, we gathered social network data from 62 Mexican-origin adults (21-40 years old) through Zoom interviews about their perceived received social support for three oral health behaviors (toothbrushing, flossing, and obtaining dental care) from three potential sources of support (family, health providers, and others/friends). Overall, we found similar results across all three oral health behaviors.

Discovery of a Novel Co-crystal of Chrysin and Oroxylin a with Anticancer Properties from Leaves of Oroxylum indicum.

Background: As the number of new cancer cases increases every year, there is a necessity to develop new drugs for the treatment of different types of cancers. Plants' resources are considered to be huge reservoirs for therapeutic agents in nature. Among all the medicinal plants, Oroxylum indicum is one of the most widely used medicinal plants in India, China, and Southeast Asian countries.

Psychosocial Determinants of Poor Dental Attendance Among Young Mexican-Identifying Adults in California.

Objective: Engagement in preventive dental care is a complex health behaviour and is determined by multiple factors. The study aimed to understand the association of psychosocial determinants with poor dental attendance.

Methods: Survey data from 333 Mexican-identifying adults in California aged 21-40-year were analysed.