Publications by authors named "A Rangchian"
Article Synopsis
- The viscoelastic properties of vitreous gel are influenced by biopolymers like collagen type II and Hyaluronic Acid, which play a crucial role in its fluid behavior.
- A study was conducted on 44 porcine vitreous samples treated with collagenase, comparing their properties to 18 control eyes injected with a saline solution, to observe changes in viscosity and elasticity over time.
- Results indicated that collagenase treatment significantly increased the creep compliance of the collagen network in the experimental group, while the Hyaluronic Acid network remained stable, highlighting structural changes in the vitreous related to collagen degradation.
Biomolecules in solutions subjected to extensional strain can form aggregates, which may be important for our understanding of pathologies involving insoluble protein structures where mechanical forces are thought to be causative (e.g., tau fibers in chronic traumatic encephalopathy (CTE)).
View Article and Find Full Text PDFThe purpose of this study is to quantify the impact of enzyme activity on the vitreous humor structure over time to understand the mechanical characteristics of the vitreous humor gel. Changes in the mechanical behavior of the vitreous occur due to many reasons including aging, which may lead to many vitreoretinal diseases. The degeneration process of the vitreous has been studied; however, in situ experimental procedures to validate the existing hypotheses are limited.
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