Publicly Available Imaging Datasets for Age-related Macular Degeneration: Evaluation according to the Findable, Accessible, Interoperable, Reusable (FAIR) Principles.

Age-related macular degeneration (AMD), a leading cause of vision loss among older adults, affecting more than 200 million people worldwide. With no cure currently available and a rapidly increasing prevalence, emerging approaches such as artificial intelligence (AI) and machine learning (ML) hold promise for advancing the study of AMD. The effective utilization of AI and ML in AMD research is highly dependent on access to high-quality and reusable clinical data.

A Novel Methodology for Establishing MCID and SCB Thresholds for Patient-Reported Outcome Measures Following Reverse Total Shoulder Arthroplasty.

Background: Increasing reliance on Patient Reported Outcome Measures (PROMs) following Reverse Total Shoulder Arthroplasty (rTSA) has resulted in variability in the thresholds for minimum clinically important difference (MCID) and substantial clinical benefit (SCB) reported in the literature. In this study, we aimed to identify the best threshold values for MCID and SCB for common rTSA PROMs.

Methods: The PubMed, Embase, MEDLINE, Cochrane Library, and Google Scholar databases were queried for studies published from January 1, 2000-March 1, 2024 that identified clinically significant thresholds for PROMs following rTSA.

Mechanical stress in a solid ellipsoid model of the lung after thoracoscopic surgery for spontaneous pneumothorax.

Background: Newly formed bullae after video-assisted thoracoscopic surgery (VATS) bullectomy in primary spontaneous pneumothorax (PSP) are an important etiology for recurrence and are associated with mechanical stress along the stapling line. However, the distribution or pattern of stress after VATS bullectomy has not been thoroughly investigated. Our aim was to analyze the stress distribution following lung resection.

Exercise-Induced Cardiac Lymphatic Remodeling Mitigates Inflammation in the Aging Heart.

The lymphatic vasculature plays essential roles in fluid balance, immunity, and lipid transport. Chronic, low-grade inflammation in peripheral tissues develops when lymphatic structure or function is impaired, as observed during aging. While aging has been associated with a broad range of heart pathophysiology, its effect on cardiac lymphatic vasculature has not been characterized.