Prophylactic efficacy of oral gabapentin on postoperative shivering: A meta-analysis of randomized controlled trials.

Background: Postoperative shivering may lead to severe side effects during postoperative care, particularly in patients with impaired cardiopulmonary function. The efficacy of oral gabapentin as a preventive strategy for postoperative shivering has not been quantitatively analyzed. In this meta-analysis, we aimed to evaluate the effectiveness of gabapentin as a drug for treating postoperative shivering.

The Adhesion GPCR ADGRL2 engages Ga13 to Enable Epidermal Differentiation.

Homeostasis relies on signaling networks controlled by cell membrane receptors. Although G-protein-coupled receptors (GPCRs) are the largest family of transmembrane receptors, their specific roles in the epidermis are not fully understood. Dual CRISPR-Flow and single cell Perturb-seq knockout screens of all epidermal GPCRs were thus performed, uncovering an essential requirement for adhesion GPCR ADGRL2 (latrophilin 2) in epidermal differentiation.

Understanding oncologic emergencies and related emergency department visits and hospitalizations: a systematic review.

Background: Patients with cancer frequently visit the emergency department (ED) and are at high risk for hospitalization due to severe illness from cancer progression or treatment side effects. With an aging population and rising cancer incidence rates worldwide, it is crucial to understand how EDs and other acute care venues manage oncologic emergencies. Insights from other nations and health systems may inform resources necessary for optimal ED management and novel care delivery pathways.

Guideline-directed medical therapies (GDMTs) for chronic kidney disease with type 2 diabetes (CKD + T2D): Translation of lessons learned from the management of heart failure.

Although guideline-directed medical therapy (GDMT) is an evidence-based, proven approach to manage chronic kidney disease and type 2 diabetes (CKD + T2DM), adherence is low and multifactorial. Opportunities exist to improve care delivery, thus delaying disease progression, avoiding unnecessary costs, and potentially improving quality of life for patients both diagnosed and yet to be diagnosed.