FAM98 Family Proteins Play Distinct Roles in Osteoclastogenesis and Bone Resorption.

There are three FAM98 family proteins (FAM98A/B/C) in humans and mice. Their physiological functions remain largely unknown. We have previously reported that Fam98a interacts with Plekhm1 in murine osteoclasts and functions in lysosome trafficking/secretion and bone resorption in osteoclasts in vitro.

6-Bromo-9,9-diethyl-,-di-phenyl-fluoren-2-amine.

In the title compound, CHBrN, the dihedral angles between the fluorene fused-ring system and the pendant phenyl groups are 67.76 (12) and 88.38 (12)°.

Do Ultracongruent Inserts Reproduce the Intraoperative Sagittal Plane Kinematics of Posterior Stabilized TKR? Assessment Using a Modern Robotic System.

Background: Ultracongruent (UC) total knee replacement (TKR) designs, serving as alternatives to posterior stabilized (PS) and cruciate retaining (CR) designs, lack conclusive evidence regarding posterior femoral rollback. This study aimed to compare intraoperative posterior femoral rollback and maximal knee flexion between UC and PS inserts, addressing the paucity of literature on femoral rollback achieved with UC designs in total knee replacement.

Methods: A consecutive cohort of 20 patients undergoing robotic-assisted primary total knee replacement, posterior femoral rollback and maximal intraoperative knee flexion were assessed.

(1-Benzo-diazol-2-ylmeth-yl)di-ethyl-amine.

In the crystal of the title compound, CHN, the mol-ecules are linked by N-H⋯N hydrogen bonds, generating a (4) chain extending along the -axis direction. One of the ethyl groups is disordered over two sets of sites with a refined occupancy ratio of 0.582 (15):0.

Frederick G Banting (1891-1941): A Pioneer in Diabetes Treatment.

The discovery of insulin by Frederick G Banting and his colleagues in 1921 marked a pivotal moment in medical history. Born in Ontario, Canada, in 1891, Banting's childhood was impacted by the death of his closest friend, Jane, who died of diabetes mellitus at a young age. This personal tragedy profoundly influenced him to choose a career in medicine and fueled his determination to find a cure for diabetes.