Electrochemical impedimetric immunosensor based on stabilized lipid bilayer-tethered WS@MWCNT for the sensitive detection of carcinoembryonic antigen.

An innovative and ultrasensitive electrochemical impedimetric immunosensor was developed for the quantitative detection towards carcinoembryonic antigen (CEA). CEA is a widely utilized tumour biomarker that is generated in a wide variety of cancers and it is a frequently used biomarker for clinical research and early detection of cancer. Novelty of the present work is the utilization of biomimetic membrane comprising gold nanoparticle-stabilized lipid bilayer (SLB) containing DOPE (1,2-dioleoyl-sn-glycero-3-phosphoethanolamine) and DOTAP (N-[1-(2,3-Dioleoyloxy)propyl]-N,N,N-trimethyl ammonium Propane) for easy protein insertion, bio-affinity, and bio-functionalization towards the detection of CEA.

1-Benzyl-4',5'-diphenyl-piperidine-3-spiro-3'-pyrrolidine-2'-spiro-3''-indoline-4,2''-dione.

The asymmetric unit of the title compound, C(34)H(31)N(3)O(2), consists of two independent mol-ecules which differ slightly in the orientations of the phenyl rings with respect to the pyrrolidine ring. In both mol-ecules, the piperidin-4-one ring adopts a chair conformation, whereas the pyrrolidine ring adopts an envelope conformation in one of the mol-ecules and a twisted conformation in the other. An intra-molecular C-H⋯O hydrogen bond is observed.