Publications by authors named "A Rajanuwong"
Article Synopsis
- A study conducted in Thailand compared the effectiveness and safety of oral versus intravenous flucytosine for treating HIV-associated cryptococcal meningitis in patients receiving amphotericin B therapy.
- The trial involved 32 patients, with no significant differences in bone marrow or liver toxicity between the two groups; all participants completed the treatment without discontinuation.
- Although intravenous flucytosine resulted in higher drug concentrations, there was no difference in early fungicidal activity compared to the oral form, suggesting both methods are safe in a developing country context and that oral bioavailability may be lower in advanced HIV patients.
Article Synopsis
- * Researchers measured different cytokines in the patient's cerebrospinal fluid (CSF) during the first two weeks of antifungal treatment, noting very low levels of certain proinflammatory cytokines compared to those with HIV-related meningitis.
- * The findings suggest that in this immunocompetent patient, an inadequate immune response may have contributed to the development of cryptococcal disease, indicating possible variability in how different patients respond to the infection.
In vitro-clinical correlations for amphotericin B susceptibility in AIDS-associated cryptococcal meningitis.
Antimicrob Agents Chemother
January 2007
Reliable measures of antifungal drug susceptibility are needed. We tested the susceptibility of Cryptococcus neoformans from patients treated with amphotericin B. In vitro susceptibility employed a modified broth macrodilution method.
View Article and Find Full Text PDFA survey of bloodstream infections was conducted in the large regional hospital in Ubon Ratchatani, northeastern Thailand between 1989 and 1998, during the onset of the HIV epidemic. The incidence of Staphylococcus aureus, Escherichia coli, Klebsiella/Enterobacter and Pseudomonas aeruginosa bacteraemias remained constant whereas infections caused by Burkholderia pseudomallei, non-typhoid Salmonellae, Cryptococcus neoformans, Penicillum marneffei and to a lesser extent Streptococcus pneumoniae all rose. Burkholderia pseudomallei infections were unrelated to HIV, whereas the other infections were associated directly with HIV.
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