Frequency-to-Place Mismatch and Cochlear Implant Outcomes by Electrode Type.

Importance: Speech recognition outcomes with a cochlear implant (CI) are highly variable. One factor suggested to correlate with CI-aided speech recognition is frequency-to-place mismatch, or the discrepancy between the natural tonotopic organization of the cochlea and the electric frequency allocation of the CI electrodes within the patient's cochlea.

Objective: To evaluate the association between frequency-to-place mismatch and speech recognition outcomes in a large cohort of postlingually deafened adult CI users, while controlling for various clinical factors known to be associated with those outcomes.

Impact of Perioperative Anticoagulation and Antiplatelet Therapy on Hearing Preservation Outcomes.

Objective: To report hearing preservation (HP) outcomes based on anticoagulation/antiplatelet use (blood thinner, BT) following cochlear implantation (CI).

Study Design: Retrospective cohort.

Setting: Tertiary referral center.

Patient Preferences in Cochlear Implant Manufacturer Selection.

Objective: To assess the factors that drive a patient's selection of cochlear implant (CI) manufacturer.

Study Design: Prospective survey study.

Setting: Tertiary referral center.

Barriers to Cochlear Implant Uptake in Adults: A Scoping Review.

Introduction: Cochlear implants (CIs) provide access to sound and help mitigate the negative effects of hearing loss. As a field, we are successfully implanting more adults with greater amounts of residual hearing than ever before. Despite this, utilization remains low, which is thought to arise from barriers that are both intrinsic and extrinsic.

Nonsense-mediated mRNA decay: Physiological significance, mechanistic insights and future implications.

Nonsense-mediated mRNA decay (NMD) is a quality control mechanism that detects and degrades premature aberrant transcripts and importantly, it also takes part in gene expression regulation by regulating the endogenous transcripts. NMD distinguishes aberrant and non-aberrant transcript by looking after the NMD signatures such as long 3' UTR. NMD modulates cellular surveillance and eliminates the plausible synthesis of truncated proteins as because if the aberrant mRNA escapes the surveillance pathway it can lead to potential negative phenotype resulting in genetic diseases.