Publications by authors named "A Rainer"
Article Synopsis
- The study presents a novel pH-responsive nanocomposite system that merges nanoparticles with cellulose to enhance drug delivery.
- Researchers utilized advanced polymerization techniques to create a copolymer that allows for uniform nanoparticle production, which effectively releases hydrophobic drugs in acidic environments.
- In vitro tests confirmed the nanoparticles' biocompatibility and their effectiveness in reducing cancer cell viability, suggesting potential for localized treatment in future therapies.
Prediction of Fragility Fractures and Mortality in a Cohort of Geriatric Patients.
J Cachexia Sarcopenia Muscle
December 2024
Article Synopsis
- Risk factors for refracture after fragility fractures include osteoporosis, female gender, and older age, but assessing functionality, muscle health, and nutrition may enhance risk prediction.
- In a study of 334 elderly patients, new fragility fractures occurred in 10.4% of individuals within two years, and the mortality rate was 12.2%; factors like lower BMI and lower parathyroid hormone levels were linked to higher fracture rates.
- Advanced age and being male significantly increased mortality risk, while adding parameters like osteosarcopenia and BMI to standard assessments improved predictive accuracy for further fractures by 10.7%.
Background: The myelin sheath ensures efficient nerve impulse transmission along the axons. Remyelination is a spontaneous process that restores axonal insulation, promoting neuroprotection and recovery after myelin damage. There is an urgent need for new pharmacological approaches to remyelination and to improve the most effective molecules.
View Article and Find Full Text PDFTwo-photon lithography has revolutionized multi-photon 3D laser printing, enabling precise fabrication of micro- and nanoscale structures. Despite many advancements, challenges still persist, particularly in biofunctionalization of 3D microstructures. This study introduces a novel approach combining two-photon lithography with scanning probe lithography for post-functionalization of 3D microstructures overcoming limitations in achieving spatially controlled biomolecule distribution.
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