Publications by authors named "A Rae-Grant"
Background And Objectives: Longitudinal outcomes in anti-NMDA receptor encephalitis (anti-NMDARe) are still not fully understood and may not be adequately captured with the modified Rankin Scale (mRS), often the sole reported outcome. We aim to characterize longitudinal outcomes in anti-NMDARe using multiple outcome measures.
Methods: This single-center, retrospective, observational study examined outcome measures (mRS and Clinical Assessment Scale in Autoimmune Encephalitis [CASE]) in adults with NMDA receptor-IgG in CSF at short- and long-term follow-ups using linear and logistic regression modeling.
Clinical Determinants of Longitudinal Disability in LGI-1-IgG Autoimmune Encephalitis.
Neurol Neuroimmunol Neuroinflamm
January 2024
Article Synopsis
- This study focuses on LGI-1-IgG autoimmune encephalitis and aims to identify factors that predict long-term disability and disease severity in patients.
- Analyzing data from 30 patients over nearly 19 months, researchers found that most patients suffered from seizures and cognitive impairment, with improvements observed in disability scores after one year.
- Key factors influencing long-term outcomes included lower initial cognitive assessment scores and specific brain MRI findings, with a majority experiencing ongoing memory issues despite some improvement in overall disability.
Background And Objectives: The purpose of this guideline is to update the 2010 American Academy of Neurology (AAN) brain death/death by neurologic criteria (BD/DNC) guideline for adults and the 2011 American Academy of Pediatrics, Child Neurology Society, and Society of Critical Care Medicine guideline for infants and children and to clarify the BD/DNC determination process by integrating guidance for adults and children into a single guideline. Updates in this guideline include guidance related to conducting the BD/DNC evaluation in the context of extracorporeal membrane oxygenation, targeted temperature management, and primary infratentorial injury.
Methods: A panel of experts from multiple medical societies developed BD/DNC recommendations.