Publications by authors named "A Rada"
Article Synopsis
- * The study found that patients with anti-LGI1 antibodies of immunoglobulin G subclasses 1, 2, or 3, in addition to subclass 4, have a significantly higher risk of developing HS compared to those with only subclass 4.
- * The research suggests that testing for these specific IgG subclasses could help identify patients at greater risk for HS, potentially guiding treatment decisions, including the consideration of anti-complement therapies.
Background And Objectives: Patients with ongoing seizures are usually not allowed to drive. The prognosis for seizure freedom is favorable in patients with autoimmune encephalitis (AIE) with antibodies against NMDA receptor (NMDAR), leucine-rich glioma-inactivated 1 (LGI1), contactin-associated protein-like 2 (CASPR2), and the gamma-aminobutyric-acid B receptor (GABAR). We hypothesized that after a seizure-free period of 3 months, patients with AIE have a seizure recurrence risk of <20% during the subsequent 12 months.
View Article and Find Full Text PDFObjective: Benchmarking has been proposed to reflect surgical quality and represents the highest standard reference values for desirable results. We sought to determine benchmark outcomes in patients after surgery for drug-resistant mesial temporal lobe epilepsy (MTLE).
Methods: This retrospective multicenter study included patients who underwent MTLE surgery at 19 expert centers on five continents.
Article Synopsis
- - Autoantibodies against Caspr2 are linked to limbic autoimmune encephalitis and pain, with 36% of patients in a study experiencing pain, which is often severe and sometimes the main symptom.
- - Two main pain phenotypes were identified: distal-symmetric burning pain and widespread pain with myalgia/cramps, highlighting variability among patients.
- - There is a correlation between anti-Caspr2 autoantibodies and pre-existing chronic pain risk factors, suggesting that these autoantibodies could indicate decreased pain sensitivity, warranting testing in patients with different types of pain.