Publications by authors named "A ROOK"
Article Synopsis
- Cutaneous T-cell lymphoma is a type of non-Hodgkin lymphoma that primarily affects the skin but may spread to other organs, with common subtypes including mycosis fungoides and Sezary syndrome.! -
- It often causes long-lasting skin rashes and can be mistaken for other skin and blood disorders, leading to significant delays in diagnosis.! -
- The review highlights key aspects such as how the condition presents, how it's diagnosed, its underlying immunology, and how to manage it effectively.!
Article Synopsis
- Many patients treated with FDA-approved CAR T cells see their disease progress, especially with solid cancers and certain types of blood cancers like T cell lymphomas.
- A major challenge in adoptive T cell therapies is the dysfunction of CAR T cells, which struggle to expand and last after being infused.
- The study reveals that knocking out the CD5 gene using CRISPR-Cas9 can improve the antitumor abilities of CAR T cells by enhancing their function and persistence, suggesting CD5 as a key target for improving T cell therapies.
Introduction: Primary cutaneous T cell lymphomas (CTCL) are a heterogenous group of non-Hodgkin lymphomas derived from skin-homing T cells. These include mycosis fungoides and its leukemic variant Sezary syndrome, as well as the CD30+ lymphoproliferative disorders.
Areas Covered: In this review, we provide a summary of the current literature on CTCL, with a focus on the immunopathogenesis and treatment of mycosis fungoides and Sezary syndrome.