Publications by authors named "A ROBERTI"
The mononuclear phagocyte system includes monocytes, macrophages, some dendritic cells, and multinuclear giant cells. These cell populations display marked heterogeneity depending on their differentiation from embryonic and bone marrow hematopoietic progenitors, tissue location, and activation. They contribute to tissue homeostasis by interacting with local and systemic immune and non-immune cells through trophic, clearance, and cytocidal functions.
View Article and Find Full Text PDFThe proper control of mitosis depends on the ubiquitin-mediated degradation of the right mitotic regulator at the right time. This is effected by the Anaphase Promoting Complex/Cyclosome (APC/C) ubiquitin ligase that is regulated by the Spindle Assembly Checkpoint (SAC). The SAC prevents the APC/C from recognising Cyclin B1, the essential anaphase and cytokinesis inhibitor, until all chromosomes are attached to the spindle.
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- - Aging leads to a decline in bodily functions and the development of various diseases, but environmental factors like lifestyle choices can impact this decline and promote healthier aging.
- - Research conducted on male mice reveals changes in the hippocampus as they age, including inflammation and issues with how mRNA is processed, along with modifications to their genetic structure.
- - By providing enriched environments for these mice, many age-related changes were reversed, particularly in pathways linked to brain support cells, suggesting that lifestyle choices can have a significant effect on aging at a molecular level.
Article Synopsis
- Loss-of-function mutations in the HTRA1 protein lead to cerebral vasculopathy, a condition that affects brain blood vessels.
- The study identifies an HTRA1 variant that effectively corrects trimer assembly defects, restoring its enzymatic function, as well as a peptidic ligand that activates HTRA1 monomers.
- Findings suggest potential strategies for targeted protein repair, offering hope for therapeutic approaches to conditions related to HTRA1 mutations.
Inflammation is a driver of human disease and an unmet clinical need exists for new anti-inflammatory medicines. As a key cell type in both acute and chronic inflammatory pathologies, macrophages are an appealing therapeutic target for anti-inflammatory medicines. Drug repurposing - the use of existing medicines for novel indications - is an attractive strategy for the identification of new anti-inflammatory medicines with reduced development costs and lower failure rates than de novo drug discovery.
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