Mannich Base Derived from Lawsone Inhibits PKM2 and Induces Neoplastic Cell Death.

Pyruvate kinase M2, a central regulator of cancer cell metabolism, has garnered significant attention as a promising target for disrupting the metabolic adaptability of tumor cells. This study explores the potential of the Mannich base derived from lawsone () to interfere with PKM2 enzymatic activity both in vitro and in silico. The antiproliferative potential of was tested using MTT assay in various cell lines, including SCC-9, Hep-G2, HT-29, B16-F10, and normal human gingival fibroblast (HGF).

Acromioclavicular Luxation with Fracture of the Lateral End of the Clavicle: Case Report.

The present case report is an observational study with a literature review. This case is significant because the injury is rare regarding location and clinical manifestation. A middle-aged male patient sustained a fracture at the acromial end of the clavicle with lateral fragment dislocation after falling from a bicycle.

Ketoprofen Associated with Hyaluronic Acid Hydrogel for Temporomandibular Disorder Treatment: An In Vitro Study.

Temporomandibular disorders (TMD) are a public health problem that affects around 12% of the global population. The treatment is based on analgesics, non-steroidal anti-inflammatory, corticosteroids, anticonvulsants, or arthrocentesis associated with hyaluronic acid-based viscosupplementation. However, the use of hyaluronic acid alone in viscosupplementation does not seem to be enough to regulate the intra-articular inflammatory process.

Polymer-Based Toothpastes and Their Ability in Control Tooth Extrinsic Stain.

Objectives: To synthesize experimental toothpastes (ETs) containing four different polymers (sodium linear polyphosphate [LPP]; chitosan [CHI]; sodium hexametaphosphate [HMP]; and sodium pyrophosphate [PP]) and test their ability in preventing and removing tooth extrinsic stain.

Methods: The tooth specimens were randomly assigned into six groups (n = 10): control (artificial saliva), regular toothpaste (RT-no whitening claim), ET 5% LPP, ET 0.5% CHI, ET 5% HMP, and ET 5% PP.

Maternal immune activation does not affect maternal microchimeric cells.

We are naturally chimeras. Apart from our own cells originating from the fertilized egg, placental mammals receive small numbers of maternal cells called maternal microchimerism (MMc) that persist throughout one's whole life. Not only are varying frequencies of MMc cells reported in seemingly contradicting phenomena, including immune tolerance and possible contribution to autoimmune-like disease, but frequencies are observable even among healthy littermates showing varying MMc frequencies and cell type repertoire.