Targeting quorum sensing in Pseudomonas aeruginosa with high-affinity inhibitors: A high-throughput screening and in-silico analysis.

Pseudomonas aeruginosa is a major pathogen in clinical settings, notorious for its intrinsic resistance to multiple antibiotics and ability to form biofilms, therefore, complicating treatment. This study reporting the results of a high-throughput screen of an antibacterial library targeting LasR, a key QS regulator in P. aeruginosa MB638, isolated from an infected surgical implant.

Zoonotic importance of ecto- and endoparasites in rodents in Malaysia: a review.

Importance: Rodents, particularly those inhabiting urban areas, are sources of infections that cause major human diseases. The number of recorded zoonotic infections has increased in recent decades, exacerbating public concerns. Zoonotic diseases in humans, such as capillariasis, hymenolepiasis, and toxoplasmosis, are life-threatening in severe cases, particularly in immunocompromised individuals.

Aptamer-Based Detection of Foot-and-Mouth Disease Virus Using Single-Stranded DNA Probe.

Foot-and-mouth disease (FMD) is known for its highly contagious properties among cloven-hoofed animals resulting in significant morbidity rates. Incursions of this disease have caused significant losses in affected countries in Southeast Asia and Africa, even within EU countries which resulted in significant financial losses. This study is aimed at addressing existing limitations by creating a diagnostic method using aptamer-based assay.

Fear of COVID-19 and mental health status among the medical students of a selected medical college in Bangladesh.

Background: COVID-19 pandemic and mental health of people are related to each other.

Aims: To assess the relationship between fear of COVID-19 (FCOV) and the psychological status of medical students of Bangladesh.

Methods: A total of 967 medical students and intern doctors of Sher-E-Bangla Medical College participated in this cross-sectional study.

Comparative Proteomics of Bacteria Under Stress Conditions.

Bacteria are unicellular organisms with the ability to exist in the harshest of climate and cope with sub-optimal fluctuating environmental conditions. They accomplish this by modification of their internal cellular environment. When external conditions are varied, change in the cell is triggered at the transcriptional level, which usually leads to proteolysis and rewiring of the proteome.