Publications by authors named "A R Wieringa"
Anidulafungin has poor oral bioavailability, with hardly any available information on how it affects breast milk, oral absorption, or gastrointestinal side effects in the infant. A 40-year-old woman who recently gave birth to a healthy infant was treated for a period of 14 days for a C with 100 mg anidulafungin once a day. The department of clinical pharmacy was consulted to provide advice on how long the patient had to wait after ceasing anidulafungin before it was safe to start breastfeeding, with regard to preventing possible side effects of the drug to the infant, such as diarrhea or cholestasis and increase in liver enzyme values.
View Article and Find Full Text PDFArticle Synopsis
- Infection-related mortality in ICU is high and inadequate beta-lactam antibiotic treatment occurs in about 45% of patients, impacting clinical success.
- The study developed and validated prediction models using data from ICU patients to forecast beta-lactam target non-attainment, utilizing variables like age, sex, and serum creatinine.
- The random forest (RF) and logistic regression (LR) models demonstrated strong performance in predicting treatment outcomes, with good discrimination and net benefit, making them useful tools for optimizing antibiotic therapy in critical care settings.
Adverse drug events caused by three high-risk drug-drug interactions in patients admitted to intensive care units: A multicentre retrospective observational study.
Br J Clin Pharmacol
January 2024
Aims: Knowledge about adverse drug events caused by drug-drug interactions (DDI-ADEs) is limited. We aimed to provide detailed insights about DDI-ADEs related to three frequent, high-risk potential DDIs (pDDIs) in the critical care setting: pDDIs with international normalized ratio increase (INR ) potential, pDDIs with acute kidney injury (AKI) potential, and pDDIs with QTc prolongation potential.
Methods: We extracted routinely collected retrospective data from electronic health records of intensive care units (ICUs) patients (≥18 years), admitted to ten hospitals in the Netherlands between January 2010 and September 2019.
Background: Phenprocoumon is a vitamin K antagonist that is widely prescribed in Europe and Latin America for the prophylaxis and treatment of thromboembolic events.
Case Presentation: A 90-year-old female was admitted to our hospital with tonic-clonic seizures, possibly due to dementia syndrome. Valproic acid (VPA) was prescribed for the treatment of seizures.
Background: Limited data exist for dosing of zanamivir in the setting of CVVH in the intensive care unit (ICU). Our objective is to report the pharmacokinetics and sieving coefficient (S) of zanamivir in patients receiving continuous venovenous hemofiltration (CVVH).
Methods: In this prospective observational study, patients of ≥18 years admitted to the ICU with a life-threatening Influenza A or B infection, treated with zanamivir i.