Publications by authors named "A R Wickremasinghe"
Background: Gastro-esophageal reflux (GORD) following sleeve gastrectomy (SG) is a central challenge, and precise indications for revisional surgery or the physiology have not been precisely defined. We aimed to determine whether OAGB performed for reflux post-SG (1) accelerates gastric emptying half-time, (2) reduces the frequency and severity of reflux events, and (3) improves reflux symptoms.
Methods: We undertook a prospective trial (ACTRN12616001089426).
Article Synopsis
- Type 2 diabetes (T2D) is a complex disease influenced by various genetic factors and molecular mechanisms that vary by cell type and ancestry.
- In a large study involving over 2.5 million individuals, researchers identified 1,289 significant genetic associations linked to T2D, including 145 new loci not previously reported.
- The study categorized T2D signals into eight distinct clusters based on their connections to cardiometabolic traits and showed that these genetic profiles are linked to vascular complications, emphasizing the role of obesity-related processes across different ancestry groups.
Improving psychological well-being among healthcare workers during the COVID-19 pandemic with an online mindfulness intervention: A randomised waitlist-controlled trial.
Int J Psychol
June 2024
The high prevalence of psychological problems observed among healthcare workers (HCWs) during the COVID-19 pandemic called for interventions to safeguard their mental health. We assessed the effectiveness of a 6-week online mindfulness-based intervention in improving well-being and reducing stress among HCWs in Sri Lanka. Eighty HCWs were recruited and randomised into two groups: waitlist-control (WLC) and intervention groups.
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- The study examines weight loss issues following laparoscopic sleeve gastrectomy (LSG) by comparing gastric emptying rates through nuclear scintigraphy and CT volumetric imaging among patients categorized by their weight loss success.* -
- Results showed that patients with optimal weight loss (OWL) experienced a significantly greater percentage of total weight loss and faster gastric emptying compared to those with poor weight loss (PWL), indicating delayed gastric emptying is linked to less weight loss effectiveness.* -
- The findings suggest that nuclear scintigraphy could be a more reliable diagnostic tool for assessing physiological function post-LSG than measuring gastric volume, as the latter did not correlate with weight loss outcomes.*
Background: Virgin coconut oil (VCO) is a potential therapeutic approach to improve cognition in Alzheimer's disease (AD) due to its properties as a ketogenic agent and antioxidative characteristics.
Objective: This study aimed to investigate the effect of VCO on cognition in people with AD and to determine the impact of apolipoprotein E (APOE) ɛ4 genotype on cognitive outcomes.
Methods: Participants of this double-blind placebo-controlled trial (SLCTR/2015/018, 15.