Publications by authors named "A R Vaillant"
Article Synopsis
- Serum HBV-RNA (seRNA) is being explored as a marker for measuring the activity of HBV replication in liver cells, and the study investigates its behavior under a specific treatment regimen.
- The trial involved 40 individuals with chronic HBV who received a combination of tenofovir, pegylated interferon, and a nucleic-acid polymer (NAP) over 48 weeks, revealing unique seRNA patterns in response to the treatments.
- Results showed that having a lower seRNA half-life was linked to achieving a partial or functional cure, suggesting that faster inactivation of cccDNA – the genetic material driving the virus – might lead to better treatment outcomes.
Near-infrared spectroscopy (NIRS) has become a popular tool for investigating phenotypic variability in plants. We developed the Shiny NIRSpredict application to get predictions of 81 Arabidopsis thaliana phenotypic traits, including classical functional traits as well as a large variety of commonly measured chemical compounds, based from near-infrared spectroscopy values based on deep learning. It is freely accessible at the following URL: https://shiny.
View Article and Find Full Text PDFIndividuals chronically infected with hepatitis B virus (HBV) and hepatitis Delta virus (HDV) present an increased risk of developing cirrhosis and hepatocellular carcinoma in comparison to HBV mono-infected individuals. Although HDV only replicates in individuals coinfected or superinfected with HBV, there is currently no in vitro model that can stably express both viruses simultaneously, mimicking the chronic infections seen in HBV/HDV patients. Here, we present the HepG2BD cell line as a novel in vitro culture system for long-term replication of HBV and HDV.
View Article and Find Full Text PDFChronic hepatitis B remains a global health problem with 296 million people living with chronic HBV infection and being at risk of developing cirrhosis and hepatocellular carcinoma. Non-infectious subviral particles (SVP) are produced in large excess over infectious Dane particles in patients and are the major source of Hepatitis B surface antigen (HBsAg). They are thought to exhaust the immune system, and it is generally considered that functional cure requires the clearance of HBsAg from blood of patient.
View Article and Find Full Text PDFArticle Synopsis
- The study looked at how different treatments for chronic hepatitis B (a liver disease) affect the virus levels and liver health.
- Participants first took one medicine alone, then some received an extra treatment while others waited longer before getting it.
- 35% of the participants were able to clear the virus completely, and those who cleared it showed a certain pattern of virus decline during treatment.