Novel anticancer drug discovery efforts targeting glycosylation: the emergence of fluorinated monosaccharides analogs.

Introduction: Glycosylation is an essential enzymatic process of building glycan structures that occur mainly within the cell and gives rise to a diversity of cell surface and secreted glycoconjugates. These glycoconjugates play vital roles, for instance in cell-cell adhesion, interaction and communication, activation of cell surface receptors, inflammatory response and immune recognition. This controlled and well-coordinated enzymatic process is altered in cancer, leading to the biosynthesis of cancer-associated glycans, which impact glycan-dependent biological roles.

New insights into the putative role of leucine-rich repeat proteins of and their participation in host cell invasion: an analysis.

Pathogenic are spirochetes that cause leptospirosis, a worldwide zoonotic disease. Leptospirosis affects humans and animals, with approximately 1 million human infections and 60,000 deaths per year. The diversity of leptospiral strains and serovars allied to the fact that pathogenesis is not yet fully understood, make the development of an effective vaccine against leptospirosis a challenge.

Systemic brain dissemination of glioblastoma requires transdifferentiation into endothelial-like cells via TGF-β-ALK1-Smad1/5 signaling.

Glioblastoma is the most aggressive type of brain cancer, but treatment improvements for glioblastoma patients remain stagnated for over 20 years. This is despite the large number of clinical trials that have attempted to replicate the success of therapeutics developed for other cancer types. This discrepancy highlights the urgent need to decipher the unique biology of glioblastomas.

Chemical characterization and antioxidant potential of Arthrospira sp., Thalassiosira sp., and Raphidonema sp.

Microalgae are emerging as valuable sources of bioactive compounds. This study evaluates hexane extracts from Thalassiosira sp. and Raphidonema sp.

Palm and interesterified palm oil-enhanced brown fat whitening contributes to metabolic dysfunction in C57BL/6J mice.

Palm oil is widely used in the food industry owing to its high stability and versatility. The interesterified version has been used as an alternative to oils rich in trans fatty acids. However, the health effects of these vegetable oils are not yet fully understood.