Publications by authors named "A R Smits"

Article Synopsis
  • Global health organizations support breastfeeding, but maternal medication can complicate this due to safety concerns about drug transfer through breast milk.
  • A systematic review was conducted to gather and analyze data on human milk intake volume using deuterium oxide dilution, comparing results with existing literature and exploring maternal factors that may affect milk intake.
  • The review included 60 studies from 34 countries involving over 5,500 infants, revealing that maternal smoking reduced milk intake, while a logarithmic regression model was developed to better understand milk intake changes based on the infant's postnatal age, highlighting the need for more data on early infancy for improved pharmacokinetic modeling.
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Article Synopsis
  • * A new cryopreservation method has been developed, allowing for the preparation of LMS from human myocardium at a later time, overcoming the limitations of immediate slice preparation after tissue extraction.
  • * Results show that cryopreserved cardiac tissue maintains structural integrity and viability comparable to fresh tissue, enabling longer and more complex experiments in cardiac research.
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Neonatal care needs more robust guidance on pharmacotherapy, (formulation, dosage regimen, safety and efficacy information). This requires structured advocacy. We therefore discuss advocacy related to improving information about medicines including current practices, clinical trials, the current setting, and trial preparedness.

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A turbulent pipe flow experiment was conducted where the surface of the pipe was oscillated azimuthally over a wide range of frequencies, amplitudes, and Reynolds numbers. The drag was reduced by as much as 35%. Past work has suggested that the drag reduction scales with the velocity amplitude of the motion, its period, and/or the Reynolds number.

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