Identification of three new HLA-DQB1 alleles: HLA-DQB1*03:02:33, -DQB1*04:79 and -DQB1*05:249.

Three new DQB1*03:02:33, DQB1*04:79 and DQB1*05:249 alleles detected in Russian individuals by next-generation sequencing.

HLA-A*02:934, identified in National bone marrow donor registry named after Vasya Perevoshchikov, Russian Federation.

HLA-A*02:934 has one nucleotide change from HLA-A*02:01:01:01 at nucleotide 308.

Mechanisms of the inhibition of endplate acetylcholine receptors by antiseptic chlorhexidine (experiments and models).

Mechanisms of the inhibition of evoked multiquantal endplate currents (EPC) by chlorhexidine (CHX) were studied in electrophysiological experiments and by mathematical modeling to discriminate between possible channel, receptor, and non-receptor effects of this common antiseptic drug. Experiments were carried out on the isolated neuromuscular preparation of the cut m. sartorius of the frog Rana ridibunda.

Model of concentration changes across the synaptic cleft during a single quantum release.

A model of concentration changes across the synaptic cleft during a single quantum release is presented that can be used for description and characterization of the kinetic in postsynaptic current development under the influence of different antagonists, modulators, desensitization promoters or complex channel blockers. The model enables the calculation of the relative number of open channels as a function of time for two standard cases - when acetylcholinesterase (AChE) is either active or inhibited. One outcome of the present model is that the variable part of AChE activity is zero at the moment of acetylcholine (Ach) release and then increases.