Publications by authors named "A R Shahed"
Aim: To determine the relationship between presumed preterm birth (PTB) etiology and the incidence of brain injury, and neurodevelopmental outcomes at 3 and 4.5 years.
Subjects And Methods: Prospective cohort study including 222 neonates born at 24-32 weeks' gestation.
Objectives: To build an early, prognostic model for adverse outcome in infants with hypoxic ischemic encephalopathy (HIE) receiving therapeutic hypothermia (TH) based on brain magnetic resonance images (MRI), electrophysiological tests and clinical assessments were performed during the first 5 days of life.
Methods: Retrospective study of 182 neonates with HIE and managed with TH. The predominant pattern of HIE brain injury on MRI performed following cooling was scored by neuroradiologists.
Article Synopsis
- - The study explored the use of remote ischemic conditioning (RIC) as a potential neuroprotective therapy for infants with neonatal encephalopathy (NE), assessing its safety and feasibility when combined with therapeutic hypothermia (TH).
- - In their randomized trial involving 32 neonates, researchers found that RIC was safe to administer, without causing any significant adverse effects or differences in seizure rates, brain injury, or mortality compared to a sham group.
- - This pilot study provides important safety data needed for future research on RIC's efficacy in improving neurodevelopmental outcomes in infants with hypoxic-ischemic encephalopathy (HIE).
Article Synopsis
- Intraventricular hemorrhage (IVH) is a major cause of brain injury in preterm infants, and this study explores the potential benefits of intranasal human milk (IHM) for treating affected infants.
- The study involved 37 infants under 33 weeks gestation with IVH who received IHM until they were 28 days old, and their outcomes were compared to 191 historic controls fed with human milk.
- Preliminary results indicated that while post-hemorrhagic ventricular dilatation was common in IHM patients, most outcomes were more favorable for IHM at later ages, suggesting the need for more comprehensive trials in this area.
Article Synopsis
- The study focused on neonates with perinatal hypoxic-ischemic encephalopathy, comparing two groups: one receiving reoriented care and another with standard care.
- Results showed that infants in the reoriented care group had worse clinical outcomes and electrographic findings, with higher injury scores on cranial ultrasounds and MRI.
- Overall, the findings suggest that reorientation of care may lead to more severe brain injury and clinical challenges in these infants.