Publications by authors named "A R Satoskar"
Leishmaniasis is a tropical disease caused by Leishmania parasites and currently has no licensed vaccines. We developed a dermotropic Leishmania major centrin gene-deleted strain (LmCen) as a live attenuated vaccine. Recent studies have shown that type I interferons (IFNs) play important roles in immunity to parasitic and viral pathogens.
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- Proteins are filtered from blood by the glomerular filtration barrier and then reabsorbed by proximal tubular epithelial cells (PTECs), which create tubular protein reabsorption droplets (TPRDs) from these proteins.
- A study analyzing 109 kidney biopsies found a negative correlation between albumin TPRDs and proteinuria, while positive correlations were observed between proteinuria and IgG TPRDs and acute tubular necrosis (ATN).
- The findings suggest that healthy PTECs are crucial for managing protein levels in urine, as their effectiveness declines with conditions like ATN, leading to increased proteinuria.
Hepatitis B-associated glomerulonephritis (GN) has been recognized for decades. However, only a few cases of IgA nephropathy (IgAN) in a setting of rapidly progressive glomerulonephritis (RPGN) associated with chronic hepatitis B virus (HBV) have been described. Herein, we report the case of a 42-year-old Asian female with a past medical history significant for chronic HBV on entecavir, hypertension, chronic kidney disease, and newly diagnosed breast cancer, who underwent elective bilateral mastectomy and breast augmentation.
View Article and Find Full Text PDFPurpose: Differentiation of the cause of left ventricular hypertrophy (LVH) is challenging in cases with co-existing hypertension. CMR offers assessment of diffuse myocardial abnormalities via T1 mapping with extracellular volume fraction (ECV) and macroscopic fibrosis via late gadolinium enhancement imaging (LGE). The goal of the study was to understand if CMR parameters can differentiate hypertensive cardiomyopathy (HC) from cardiac amyloidosis (CA) in patients with hypertension and heart failure, using endomyocardial biopsy (EMB) as the gold standard.
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