Publications by authors named "A R Sacker"
Article Synopsis
- Research investigates the link between socioeconomic position (SEP) and the transition between cognitive states, including neurocognitive impairment and mortality risk.
- The study found significant differences in cognitive state transitions based on SEP, revealing that higher wealth is associated with a greater likelihood of improving cognitive function.
- Additionally, lower education levels correlate with increased mortality risk following dementia onset, suggesting that socioeconomic factors may influence both cognitive health and longevity.
Article Synopsis
- Individuals in out-of-home care during childhood have an increased risk of developing cardiovascular disease in adulthood, with a 51% higher risk compared to those who weren't placed in care.
- The research pooled results from twelve studies (two published and ten unpublished), involving over 611,000 individuals across multiple countries (US, UK, Sweden, Finland, Australia).
- The studies were rigorously selected based on specific criteria, and five of them were rated high in methodological quality, ensuring reliable outcomes for the assessment of cardiovascular risks.
Accurate surgical pathological assessment of breast biopsies is essential to the proper management of breast lesions. Identifying histological features, such as nuclear pleomorphism, increased mitotic activity, cellular atypia, patterns of architectural disruption, as well as invasion through basement membranes into surrounding stroma and normal structures, including invasion of vascular and lymphatic spaces, help to classify lesions as malignant. This visual assessment is repeated on numerous slides taken at various sections through the resected tumor, each at different magnifications.
View Article and Find Full Text PDFBackground: Individuals who were separated from their biological family and placed into the care of the state during childhood (out-of-home care) are more prone to developing selected physical and mental health problems in adulthood, however, their risk of cardiovascular disease (CVD) is uncertain. Accordingly, we pooled published and unpublished results from cohort studies of childhood care and adult CVD.
Methods: We used two approaches to identifying relevant data on childhood care and adult CVD (PROSPERO registration CRD42021254665).
Article Synopsis
- Socioeconomic position is linked to inflammation, which may play a role in the connection between socioeconomic inequalities and neurocognitive disorders in older adults. The study used data from the English Longitudinal Study of Ageing (ELSA) to explore this relationship.
- Researchers found that higher education, occupation, and wealth are associated with a lower risk of cognitive impairment and dementia over time, highlighting the importance of socioeconomic factors on brain health.
- Inflammatory markers, particularly white blood cells, C-Reactive Protein (CRP), and plasma fibrinogen, were identified as mediators in the relationship between socioeconomic position and cognitive impairment, emphasizing the complex interplay between lifestyle factors, inflammation, and neuroc