Publications by authors named "A R Ruszkiewicz"
Article Synopsis
- - The study explored the effects of injecting phosphorus-32 (P) microparticles into pancreatic tumors during chemotherapy (FOLFIRINOX) to improve poor blood flow—which hinders treatment responses—in patients with locally advanced pancreatic cancer (LAPC).
- - Out of 20 patients, the results showed a significant decrease in tumor size and increased vascularity after P implantation, with 25% achieving tumor downstaging and four patients opting for surgery.
- - Most patients (75%) remained alive after an average follow-up of 11.2 months, but the study found no significant difference in overall survival between patients who showed increased tumor blood flow and those who did not.
Background: Chimeric antigen receptor (CAR) T cell therapies specific for the CD19 and B-cell maturation antigen have become an approved standard of care worldwide for relapsed and refractory B-cell malignancies. If CAR-T cell therapy for non-hematological malignancies is to achieve the same stage of clinical development, then iterative early-phase clinical testing can add value to the clinical development process for evaluating CAR-T cell products containing different CAR designs and manufactured under differing conditions.
Methods: We conducted a phase 1 trial of third-generation GD2-specific CAR-T cell therapy, which has previously been tested in neuroblastoma patients.
Introduction: Eosinophilic esophagitis (EoE) is associated with atopy; however, recent studies have identified an association with food-specific immunoglobulin G 4 (FS-IgG 4 ) rather than immunoglobulin E antibodies. This study aimed to evaluate the role of serum FS-IgG 4 in guiding an elimination diet and its outcomes.
Methods: Patients with and without EoE were enrolled in a prospective, controlled, single tertiary center trial.
Background: The impact of RAS/BRAF mutation on primary response rates after total neoadjuvant therapy (TNT) in patients with advanced rectal cancer is unclear. The aim of this study was to assess complete response rates after TNT according to RAS/BRAF mutation status.
Methods: A prospective observational study was performed in patients with rectal cancer who underwent TNT with curative intent at three South Australian hospitals between 2019 and 2023.
A case report of an oesophageal duplication cyst in an adult patient with chronic cough and presenting with a "coughed out lump". This is an unusual presentation highlighting the importance of considering congenital duplication cysts in patients with chronic cough and no obvious respiratory cause.
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