AnchorFCI: harnessing genetic anchors for enhanced causal discovery of cardiometabolic disease pathways.

Introduction: Cardiometabolic diseases, a major global health concern, stem from complex interactions of lifestyle, genetics, and biochemical markers. While extensive research has revealed strong associations between various risk factors and these diseases, latent confounding and limited causal discovery methods hinder understanding of their causal relationships, essential for mechanistic insights and developing effective prevention and intervention strategies.

Methods: We introduce anchorFCI, a novel adaptation of the conservative Really Fast Causal Inference (RFCI) algorithm, designed to enhance robustness and discovery power in causal learning by strategically selecting and integrating reliable anchor variables from a set of variables known not to be caused by the variables of interest.

Health literacy assessment of individuals with and without Chagas disease: a cross-sectional study.

Background: Chagas disease (CD) is neglected that affects vulnerable individuals, whose majority has low ability to understand health information.

Objectives: To assess health literacy and its association with sociodemographic, clinical, and quality of life (QoL) characteristics.

Design And Setting: A cross-sectional study the participants with Chagas disease (ChD) were identified through serological diagnosis during blood donation, while those without the disease were seronegative blood donors.

Social Support and Postpartum Depressive Symptoms in Portuguese Women: The Mediating Role of Emotion Regulation Difficulties.

Postpartum depression (PPD) is a prevalent mental health issue affecting 14% of mothers worldwide, with long-term implications for both maternal and child well-being. Understanding the factors contributing to PPD is essential for developing effective interventions. This study aimed to investigate the relationship between social support and postpartum depression symptoms, with a focus on the mediating role of emotion regulation difficulties.

Compatibilizer Efficiency in Enhancing Marine Plastic Waste Valorization Through Simulated Recycled Plastic Blends.

This study investigated the optimal combination of compatibilizers and stabilizers to enhance the value of marine environment plastic (MEP). The composition of the plastics was analysed, and a simulated recycled plastic blend (sMEP) was prepared based on a simplified composition of actual MEP. Different concentrations of three commercial compatibilizers (C1, C2 and C3) were tested to improve tensile strength.

The Elusive Biological Activity of Scorpionates: A Useful Scaffold for Cancer Therapy?

Cancer remains a formidable challenge, requiring the constant pursuit of novel therapeutic agents and strategies. Scorpionates, known for their unique coordination properties, have recently gained attention for their anticancer potential. Traditionally applied in catalysis, these compounds have demonstrated notable cytotoxicity across various cancer cell lines, often surpassing the efficacy of conventional chemotherapeutics.