[Changes in the immune status of patients with brain tumors in the pre- and postoperative periods].

Changes of the immune status in patients with glioblastomas and meningiomas during the stages of surgical treatment were studied. Functional activity of lymphocytes suffers to a greater measure in patients in the preoperative period and the ratio of the lymphocyte T- and B-subpopulations changes. Preoperative management including hormonal therapy causes further inhibition of the immune status but has no effect on the degree of neurosensitization of the patients, which may be a risk factor of the development of postoperative complications of infectious-inflammatory neuroallergic etiology.

[The use of myelopid in the combined treatment of infectious-inflammatory complications in the postoperative period in neuro-oncology patients].

Clinical observations over 48 neurosurgical patients with infectious inflammatory complications and study of their immune status showed that a course of immunocorrective therapy with myelopid produces a favourable clinical effect and normalizes the patient's immune status. Myelopid causes the best normalizing effect in patients with nontumorous pathology of the central nervous system and in extracerebral neoplasms.

[Lymphocyte subpopulations and their functional activity in patients with brain tumors].

The authors studied a complex of immunological indices in 69 patients with brain tumours in the pre- and postoperative period. It is shown that in patients with benign brain tumours, preoperative care and surgical intervention largely alter the functional activity of T and B-lymphocytes while patients with malignant tumours of the brain revealed less pronounced changes of quantitative indices of definite subpopulations of lymphocytes against the background of marked reduction of their functional activity. The necessity is emphasized of complex evaluation of immunological indices in patients with brain tumours.

[The pathomorphological characteristics of the action on the body of the antitumor antibiotic asterin under stress conditions].

The action (on the organism) of antitumour antibiotic asterine isolated from plant of family Asteraceae under stress conditions at D. K. Zabolotnyĭ Institute of Microbiology and Virology has been pathomorphologically characterized.

[The effect of surgical intervention on the state of the immune system in brain tumors].

In patients with benign and malignant brain tumors before the operation, the suppression of the immune system, in particular, proliferative response of lymphocytes to T- and B-mitogens was established. Preoperative preparation of the patients aggravated this process. At day 8-10 after the operation, normalization of the main indices of immunity in patients with benign tumors was noted.