Natural Tolerance Development to Peach in a Child with Lipid Transfer Protein Allergy.

Non-specific lipid transfer proteins (LTPs), present in multiple plant foods and pollens, are the predominant allergen in peach allergy in the Mediterranean region and may induce life-threatening allergic reactions. Although reasonably studied in adults, LTP allergy has been rarely described in children, and to the best of the author's knowledge, natural tolerance development during childhood to this allergen has not been reported to date. The authors reported the case of a 21 month-old boy who presented urticaria and facial edema 15 minutes after eating a peach.

Allergy to lipid transfer proteins (LTP) in a pediatric population.

Lipid transfer proteins (LTP) are considered important plant food allergens in the Mediterranean area, but little is known about LTP allergy in pediatric age. Our aim was to characterize LTP allergy in children. We reviewed the clinical data from all children evaluated in our department with LTP allergy.

Photoactivation of the Cytotoxic Properties of Platinum(II) Complexes through Ligand Photoswitching.

The development of photoactivatable metal complexes with potential anticancer properties is a topical area of current investigation. Photoactivated chemotherapy using coordination compounds is typically based on photochemical processes occurring at the metal center. In the present study, an innovative approach is applied that takes advantage of the remarkable photochemical properties of diarylethenes.

Non-Switching 1,2-Dithienylethene-based Diplatinum(II) Complex Showing High Cytotoxicity.

A diplatinum(II) complex was prepared from a new 1,2-dithienylethene-based ligand containing N-methylimidazole groups as metal-binding units. Reaction of the ligand 1,2-bis[2-methyl-5-(1-methyl-1H-imidazol-2-yl)-3-thienyl]-cyclopentene (L2(H)) with cis-dichlorobis(dimethylsulfoxido)platinum(II) generated the bimetallic complex trans-[Pt2Cl4(DMSO)2(L2(H))] (DMSO = dimethyl sulfoxide), whose DNA-interacting properties were investigated using different techniques. Cytotoxicity assays with various cancer cell lines showed that this compound is active, with IC50 values in the micromolar range.

Photoswitching the cytotoxic properties of platinum(II) compounds.

The photoactivation of potential anticancer metal complexes is a hot topic of current research as it may lead to the development of more selective drugs. Photoactivated chemotherapy (PACT) with coordination compounds is usually based on a (photo)chemical reaction taking place at the metal center. Herein, a new strategy is exploited that consists of "photomodifying" a ligand coordinated to metal ions.