Publications by authors named "A R Poppe"
Background: Antiphospholipid syndrome (APS) is a systemic autoimmune disorder characterized by thrombosis, pregnancy complications, and other nonthrombotic manifestations in the presence of antiphospholipid antibodies. Neurovascular complications, including ischemic stroke, cerebral venous thrombosis and cognitive impairment, pose significant challenges in management.
Objective: To comprehensively review relevant and updated clinical aspects of neurovascular manifestations of APS.
Background: In the ESCAPE-NA1 trial (Efficacy and Safety of Nerinetide for the Treatment of Acute Ischemic Stroke), treatment with nerinetide was associated with a smaller infarct volume among patients who did not receive intravenous alteplase. We assessed the effect of nerinetide on the surrogate imaging outcome of final infarct volume in patients who did not receive intravenous alteplase and explored predictors of outcome and modifiers of nerinetide's effect on infarct volume.
Methods: ESCAPE-NA1 was a multicenter, randomized trial in which patients with acute stroke with a baseline Alberta Stroke Program Early CT Score >4, undergoing endovascular thrombectomy, were randomized to receive intravenous nerinetide or placebo.
Article Synopsis
- Carotid plaques may play a significant role in causing ischemic strokes, and this study evaluated their characteristics in relation to strokes that occur on either side of the affected carotid artery.
- Researchers analyzed data from the ESCAPE-NA1 trial, focusing on patients with embolic stroke of undetermined source (ESUS) who underwent thrombectomy, and looked for "vulnerable carotid plaques" using various imaging criteria.
- The findings revealed that vulnerable plaques, characterized by surface irregularity and significant stenosis, were significantly more common in the carotid arteries on the same side as the stroke, highlighting the importance of monitoring these plaques for better stroke risk assessment.
Purpose: The modified Rankin Scale (mRS) at 90 days is the primary outcome in most acute stroke studies, but the long follow-up period has disadvantages. The National Institutes of Health Stroke Scale (NIHSS) at 24 h shows a strong, but imperfect, association with 90-day mRS. This study examines the association between 24-hour NIHSS and 90-day mRS and reasons for discrepancies.
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