Subcutaneous silicone injection leading to multi-system organ failure.

Background: Silicone is an inert liquid polymer often chosen for cosmetic procedures due to its durability and thermal stability. Following silicone injection, end organ toxicity can occur. We report two cases of multiorgan dysfunction following silicone injection.

Two human cDNAs, including a homolog of Arabidopsis FUS6 (COP11), suppress G-protein- and mitogen-activated protein kinase-mediated signal transduction in yeast and mammalian cells.

We have isolated two novel human cDNAs, gps1-1 and gps2, that suppress lethal G-protein subunit-activating mutations in the pheromone response pathway of the yeast Saccharomyces cerevisiae. Suppression of other pathway-activating events was examined. In wild-type cells, expression of either gps1-1 or gps2 led to enhanced recovery from cell cycle arrest induced by pheromone.