Publications by authors named "A R Nusrat"
Nerve injury causes neuropathic pain and multilevel nerve barrier disruption. Nerve barriers consist of perineurial, endothelial and myelin barriers. So far, it is unclear whether resealing nerve barriers fosters pain resolution and recovery.
View Article and Find Full Text PDFSusceptibility to inflammatory bowel diseases (IBDs), Crohn's disease (CD), and ulcerative colitis (UC) is linked with loss of intestinal epithelial barrier integrity and mitochondria dysfunction. Steroidogenic acute regulatory (StAR) protein-related lipid transfer (START) domain-containing protein 7 (STARD7) is a phosphatidylcholine-specific (PC-specific) lipid transfer protein that transports PC from the ER to the mitochondria, facilitating mitochondria membrane stabilization and respiration function. The aim of this study was to define the contribution of STARD7 in the regulation of the intestinal epithelial mitochondrial function and susceptibility to colitis.
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- Spatial transcriptomics (ST) technologies allow for in-depth gene expression analysis at a very fine scale, but traditional methods face challenges due to complex tissue structures and irregular cell shapes.
- The new method, FICTURE, offers a segmentation-free approach that can analyze large-scale transcriptome data with submicron precision, making it compatible with different types of ST data.
- FICTURE is significantly more efficient than existing methods and improves our understanding of intricate tissue architectures in challenging areas like vascular and fibrotic tissues, enhancing the exploration of high-resolution spatial transcriptomics.
Article Synopsis
- Interferon-gamma (IFNγ) has a dual role in intestinal inflammation, being known for its pro-inflammatory effects while also promoting repair by boosting TNFα receptor 2 expression in intestinal epithelial cells.
- Research indicates that IFNγ signals through the transcription factor STAT1 to enhance TNFR2 expression after cell injury, both in lab settings and live models.
- The study reveals that neutralizing IFNγ after intestinal injury hinders healing, suggesting that the timing and levels of IFNγ and TNFα are crucial for restoring tissue balance, challenging the idea that all pro-inflammatory agents only cause harm.
Thrombospondin-1 (TSP1) is a matricellular protein associated with the regulation of cell migration through direct binding interactions with integrin proteins and by associating with other receptors known to regulate integrin function, including CD47 and CD36. We previously demonstrated that deletion of an epithelial TSP1 receptor, CD47, attenuates epithelial wound repair following intestinal mucosal injury. However, the mechanisms by which TSP1 contributes to intestinal mucosal repair remain poorly understood.
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