Publications by authors named "A R Muir"
In homeostatic conditions, the basal progenitor cells of the esophagus differentiate into a stratified squamous epithelium. However, in the setting of acid exposure or inflammation, there is a marked failure of basal cell differentiation, leading to basal cell hyperplasia. We have previously shown that lysyl oxidase (LOX), a collagen crosslinking enzyme, is upregulated in the setting of allergic inflammation of the esophagus; however, its role beyond collagen crosslinking is unknown.
View Article and Find Full Text PDFACG Clinical Guideline: Diagnosis and Management of Eosinophilic Esophagitis.
Am J Gastroenterol
January 2025
Article Synopsis
- Eosinophilic esophagitis (EoE) is a chronic immune disease characterized by symptoms of esophageal dysfunction and an eosinophil-dominated infiltration in the esophagus.
- The incidence of EoE is rising, requiring attention in various medical settings, leading to updated guidelines that focus on improved diagnosis and treatment strategies.
- Recommended treatments include proton pump inhibitors, topical steroids, dietary elimination, and esophageal dilation, with an emphasis on monitoring patients for treatment response and managing both inflammatory and structural aspects of the disease.
PPP2R5C encodes a B-type regulatory subunit of protein phosphatase 2A (PP2A). This protein serine/threonine phosphatase is a component of multiple signaling pathways and is an established negative regulator of cell division, growth, and proliferation. De novo variants in other subunits of PP2A are associated with neurodevelopment disorders and intellectual disability (ID).
View Article and Find Full Text PDFA stimulus-responsive indole-based hydrogen bonding switch is reported, which enables off-on activation of transmembrane ion transport in response to photo- and redox triggers. This is achieved by alkylation of an indole-based anionophore, preorganized through intramolecular hydrogen bonding, with -nitrobenzyl and azobenzene cages. This renders the anionophore inactive through formation of a six-membered intramolecular hydrogen bonding interaction and locking of the anion binding protons.
View Article and Find Full Text PDFObjective: To evaluate the sedation quality of an IM injection of a commercially available medetomidine-vatinoxan combination (ZEN) in healthy goats and sheep and discern species differences in cardiopulmonary parameters.
Methods: 10 apparently healthy adult university-owned research Black Bengal-crossbreed goats and 10 adult Gulf Coast native and Katahdin sheep were enrolled in this prospective experimental study from June 27 to July 27, 2023. All animals were sedated on 1 occasion with 0.