Biomechanical correlates of gait and stair climbing are associated with ex vivo cartilage quality in gonarthrotic patients.

Previous evidence highlights the important role of knee joint malalignment and excessive joint moments for the development to knee osteoarthritis. The present study aimed to systematically investigate the interrelationship between three-dimensional knee kinematics during walking and stair climbing and ex-vivo electromechanical measured cartilage quality in 119 patients with end-stage knee osteoarthritis. Patients scheduled for total knee arthroplasty surgery underwent radiographic assessment and biomechanical analysis in gait and stair climbing assessing in vivo knee joint angles and moments during movement dynamics prior to surgery.

Proportional mortality and years of potential life lost due to liver diseases among agricultural workers, Brazil, 2017 to 2022.

This study aimed to describe the profile and calculate the years of potential life lost (YPLL) due to liver diseases in Brazilian agricultural workers from 2017 to 2022. For this, we analyzed microdata available in the Brazilian Mortality Information System considering the underlying cause of death with codes K70-K77 (International Classsification of Disease, 10th revision - ICD-10) as the outcome of interest. Workers' profile was characterized according to sociodemographic variables and Brazilian regions, forming a comparison group with all other Brazilian workers aged from 18-69 years who died in the same period and from the same underlying cause.

Proteomic profiling of zinc homeostasis mechanisms in through data-dependent and data-independent acquisition mass spectrometry.

Zinc is central to the function of many proteins, yet the mechanisms of zinc homeostasis and their interplay with other cellular systems remain underexplored. In this study, we employ data-dependent acquisition (DDA) and data-independent acquisition (DIA) mass spectrometry to investigate proteome changes in under conditions of different zinc availability. Using these methods, we detected 2143 unique proteins, 1578 of which were identified by both DDA and DIA.

Autism, ADHD, and Their Traits in Adults With Bulimia Nervosa and Binge Eating Disorder: A Scoping Review.

Objective: This review maps existing literature on the prevalence of autism and ADHD in adult patients with Bulimia Nervosa (BN) and Binge Eating Disorder (BED); patient and stakeholder perspectives on this comorbidity; clinical differences in this population; and potential treatment adaptations or adjunct therapies. This is with the aim to inform future research priorities to improve clinical practice.

Method: As pre-registered, and following PRISMA guidelines, six databases (Embase, MEDLINE via Ovid, PsycINFO, Web of Science, CENTRAL, and Scopus) were searched for studies regarding autism and/or ADHD (diagnosed, probable, or traits) in adult patients with BN or BED.