Clinical and Laboratory Characteristics and Comorbidities in Asthma Endotypes in Children.

Objective: To estimate the proportion of eosinophilic and non-eosinophilic (NEA) endotypes in pediatric asthma, and to compare the clinical, and laboratory characterisitics, and different comorbidities between the two endotypes in the children.

Methods: Children aged 5 to 14 years of age with clinical and/or laboratory-confirmed asthma attending the pediatric outpatient department of a tertiary care hospital in Eastern India between October 1, 2023 and March 31, 2024, were included in this cross-sectional study. Complete hemogram, absolute eosinophil count (AEC), IgE, and pulmonary function tests were performed in all patients.

Basic Science and Pathogenesis.

Background: Diabetes increases the risk of Alzheimer's disease (AD), and mitochondrial dysfunction is implicated in both diseases. We previously detected mitochondrial DNA copy number (MtDNA-CN) changes in human parietal cortex that differed between diabetic AD and non-diabetic AD. We hypothesize that MtDNA-CN changes may be indicative of different underlying mechanisms.

Predicting Microvascular Invasion in Liver Transplant Recipients for Hepatocellular Carcinoma.

Background: Among primary liver tumors, hepatocellular carcinoma (HCC) is considered the most common hepatic tumor. Liver transplantation is one of the curative treatment options for HCC. However, the risk of HCC recurrence after liver transplantation varies and is influenced by various factors.

Unraveling the Effects of Hexametaphosphate: Insights into Trypsin Aggregation and Structural Reversal.

Elevated serum phosphate levels have been linked to increased mortality rates. This study investigated the effect of millimolar (mM) concentrations of sodium hexametaphosphate (SHMP) on trypsin's aggregation and structural stability at intestinal pH levels. We used various spectroscopic and microscopic techniques to investigate the structural changes of trypsin aggregates.

Phytochemical characterization and anti-arthritic potential of green-synthesized CuO nanoparticles derived from the root extract.

Introduction: Rheumatoid arthritis is an autoimmune disease that mainly causes joint damage. The patient experiences loss of appetite, pain, fever, and fatigue. The present study was designed to phytochemically characterize and evaluate the anti-arthritic activity of green-synthesized copper oxide (CuO) nanoparticles (NPs) using the hydroalcoholic extract of roots in an adjuvant-induced arthritic rat model.