Publications by authors named "A R M Bradbury"
Some genetic counselors (GCs) may find theories, models, and frameworks (TMFs) useful in clinical skills selection and when reflecting on or evaluating genetic counseling practice. This paper aims to demonstrate how TMFs can be used to postulate how different skills may impact patients'/clients' decisions, behaviors, and outcomes and consider how multiple TMFs can inform the use of various skills or strategies to achieve different goals. Additionally, we provide examples of TMFs that may help GCs in nonclinical aspects of their work, such as implementing and evaluating new interventions or service delivery models.
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- The study investigates the effectiveness and cost-efficiency of two surgical approaches (vein bypass-first vs. best endovascular treatment-first) for treating chronic limb-threatening ischemia, which can lead to pain and tissue loss.
- Conducted in 40 medical centers across the UK, Sweden, and Denmark, the trial involved patients requiring revascularization due to atherosclerotic peripheral arterial disease.
- Key outcomes measured included amputation-free survival, overall survival rates, major amputations, quality of life, and costs associated with hospital treatments over a follow-up period of at least 2 years.
Article Synopsis
- The text discusses a new platform for creating antibodies with high effectiveness and diversity, building on a previously established single-chain fragment (scFv) library that used clinical antibodies as a base.
- This advancement involves using Fab phage display followed by scFab yeast display, resulting in better expression balance of antibody chains and improved conversion rate to IgG antibodies, combining the benefits of scFvs and Fabs.
- A quality-controlled Fab phage library was developed, showcasing its potential to produce a diverse range of binding scFabs with high efficiency, ultimately streamlining the path for these antibodies to become viable therapeutic options.