Publications by authors named "A R Lazzaro"
While much is known about the expression of interferon (IFN) pathways in the blood of people living with HIV (PLWH), their role in the intesinal tract has only recently been appreciated. The aim of this study was to evaluate gut mRNA expression levels of innate immune genes involved in the HIV-host interaction and their association with CD4T cell immune activation in long-term HAART-experienced PLWH. PLWH had increased intestinal levels of TLR4, type I IFN (IFN-α2, IFN-α14, IFN-β) and IFNAR1 mRNAs, as well as increased frequencies of CD4T lymphocytes expressing CD38 or HLA-DR compared to the healthy donors.
View Article and Find Full Text PDFIsatuximab, pomalidomide, and dexamethasone as salvage therapy for patients with multiple myeloma: the Italian, multicenter, retrospective clinical experience with 270 cases outside of controlled clinical trials.
Haematologica
November 2024
Article Synopsis
Isatuximab, a novel anti-CD38 monoclonal antibody, is approved in combination with carfilzomib and dexamethasone (Isa-Kd) in relapsed/refractory multiple myeloma (RRMM) patients. Because of its recent introduction, real-world efficacy and safety are poorly reported. In this Italian multicenter real-life observational retrospective study, efficacy and safety of the Isa-Kd regimen were evaluated in a cohort of 103 RRMM patients.
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- The study investigated the impact of switching to a less neurotoxic antiretroviral therapy (ARV) on neurocognitive performance in people living with HIV who have cognitive impairments.
- Participants were randomly assigned to either continue their current treatment or switch to a less harmful ARV regimen (MARAND-X) for 24 weeks, with results measured using various cognitive tests and electroencephalography.
- While the overall neurocognitive scores improved modestly, significant improvements were only seen in specific memory functions for those in the MARAND-X group with better CNS penetration, indicating that the effectiveness of ARVs in the central nervous system may influence cognitive health.
Parathyroid carcinoma (PC) is a rare malignancy, often characterized by the unregulated secretion of parathyroid hormone. The sequelae of severe hypercalcemia together with direct complications from tumor dissemination in patients with advanced disease are usually fatal. Due to its rarity, formal studies to guide the diagnosis and management of parathyroid carcinoma are lacking.
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