Resting beat-to-beat blood pressure variability in humans: role of alpha-1 adrenergic receptors.

Purpose: Resting beat-to-beat blood pressure variability is a strong predictor of cardiovascular events and mortality. However, its underlying mechanisms remain incompletely understood. Given that the sympathetic nervous system plays a pivotal role in cardiovascular regulation, we hypothesized that alpha-1 adrenergic receptors (the main sympathetic receptor controlling peripheral vasoconstriction) may contribute to resting beat-to-beat blood pressure variability.

Engineering Gene and Protein Switches for Regulation of Lineage-Specifying Transcription Factors.

Human pluripotent stem cells (hPSCs) can be differentiated in vitro to an increasing number of mature cell types, presenting significant promise for addressing a wide range of diseases and studying human development. One approach to further enhance stem cell differentiation methods would be to coordinate multiple inducible gene or protein switches to operate simultaneously within the same cell, with minimal cross-interference, to precisely regulate a network of lineage-specifying transcription factors (TFs) to guide cell fate decisions. Therefore, in this study, we designed and tested various mammalian gene and protein switches responsive to clinically safe small-molecule inhibitors of viral proteases.

Brain-Derived Neurotrophic Factor (BDNF) as a Potential Biomarker in Brain Glioma: A Systematic Review and Meta-Analysis.

Background: This systematic review and meta-analysis evaluates peripheral and CNS BDNF levels in glioma patients.

Methods: Following PRISMA guidelines, we systematically searched databases for studies measuring BDNF in glioma patients and controls. After screening and data extraction, we conducted quality assessment, meta-analysis, and meta-regression.

Exploring the Variability in Phenolic Compounds and Antioxidant Capacity in Olive Oil By-Products: A Path to Sustainable Valorization.

The olive oil industry generates large volumes of by-products, creating notable environmental and economic concerns. Among these, olive cake (OC)-a primary by-product of olive oil extraction-stands out due to its high content of bioactive compounds and potential for value-added recycling. This study focused on characterizing six OC samples from the Trás-os-Montes and Alto Douro regions, collected at different processing times and mills.

Printed versus heat-polymerized resin for occlusal devices: Evaluation of physical and mechanical properties after brushing and microbial adhesion.

Purpose: To evaluate the physical and mechanical properties after brushing and microbial adhesion of printed resins (PRs) and heat-polymerized resins (HRs) for occlusal devices (ODs).

Materials And Methods: Knoop microhardness and roughness were evaluated in three measurements before and after brushing with detergent or dentifrice. Flexural strength and modulus of elasticity were assessed by 3-point bending, and the adhesion of Candida albicans and Streptococcus mutans was evaluated by colony-forming units per milliliter (CFU/mL) and metabolic activity using the XTT assay only without brushing.