Publications by authors named "A R Kunwar"
MindScape Study: Integrating LLM and Behavioral Sensing for Personalized AI-Driven Journaling Experiences.
Proc ACM Interact Mob Wearable Ubiquitous Technol
November 2024
Mental health concerns are prevalent among college students, highlighting the need for effective interventions that promote self-awareness and holistic well-being. MindScape explores a novel approach to AI-powered journaling by integrating passively collected behavioral patterns such as conversational engagement, sleep, and location with Large Language Models (LLMs). This integration creates a highly personalized and context-aware journaling experience, enhancing self-awareness and well-being by embedding behavioral intelligence into AI.
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- The concept of "oxidative stress," introduced by Helmut Sies, has been pivotal in redox biology, highlighting the imbalance of oxidants in various diseases, particularly cancer.
- Pharmacological strategies have been developed to either induce oxidative stress in cancer cells or use antioxidants to prevent cancer formation.
- Recent research suggests that "reductive stress," or the accumulation of reducing agents, might also play a role in cancer development, presenting new opportunities for chemotherapeutic strategies and improving outcomes in radiation therapy.
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- Hereditary Neuralgic Amyotrophy (HNA) is an autosomal dominant disorder linked to mutations in the SEPTIN9 gene, causing episodes of severe pain and muscle atrophy, particularly affecting the brachial plexus.
- * In a study of a large family with HNA, genetic analysis showed a mutation (NM_001113491.2:p.Arg106Trp) in the SEPTIN9 gene present in six affected members, leading to significant changes in the protein's structure and function.
- * Despite sharing the same genetic mutation, affected family members exhibited a wide range of symptoms, suggesting that factors such as variable penetrance and epigenetic influences may contribute to this variability.
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- In 2018, the Navi Mumbai Municipal Corporation launched a typhoid vaccine campaign aimed at children aged 9 months to 14 years.
- The study analyzed factors influencing vaccine receipt using statistical methods and found that school enrollment, low household income, and community-level socioeconomic status significantly increased vaccine uptake.
- The campaign effectively targeted and vaccinated underserved populations, improving access to healthcare among the most vulnerable demographics.
Septins: Structural Insights, Functional Dynamics, and Implications in Health and Disease.
J Cell Biochem
September 2024
Septins are a class of proteins with diverse and vital roles in cell biology. Structurally, they form hetero-oligomeric complexes and assemble into filaments, contributing to the organization of cells. These filaments act as scaffolds, aiding in processes like membrane remodeling, cytokinesis, and cell motility.
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