Publications by authors named "A R J Manktelow"
Background: Trabecular metal is being increasingly used in primary total hip arthroplasty (THA). This study compared medium-term (< 15 years) outcomes of fiber mesh titanium and trabecular metal acetabular components.
Methods: This study included 6,563 patients who underwent primary THA with either fiber mesh titanium or trabecular metal-backed acetabular components.
Article Synopsis
- Post-mortem studies reveal that patients who died from COVID-19 often show brainstem damage, which may result from immune responses during and after the infection.
- Symptoms such as fatigue, breathlessness, and chest pain in post-hospitalization COVID-19 patients may be linked to these brainstem abnormalities.
- Using advanced MRI techniques, a study found increased susceptibility in key brainstem regions of COVID-19 survivors, indicating a correlation between these changes and the severity of their illness and recovery outcomes.
Importance: The chronic neuronal burden of traumatic brain injury (TBI) is not fully characterized by routine imaging, limiting understanding of the role of neuronal substrates in adverse outcomes.
Objective: To determine whether tissues that appear healthy on routine imaging can be investigated for selective neuronal loss using [11C]flumazenil (FMZ) positron emission tomography (PET) and to examine whether this neuronal loss is associated with long-term outcomes.
Design, Setting, And Participants: In this cross-sectional study, data were collected prospectively from 2 centers (University of Cambridge in the UK and Weill Cornell Medicine in the US) between September 1, 2004, and May 31, 2021.
Article Synopsis
- Neuroscientists are using network science to study interactions between brain regions, focusing on how to reconstruct these networks from resting-state functional MRI data.
- The study evaluates 768 different data-processing pipelines, considering factors like brain parcellation and sensitivity to movement, to identify which are best for analyzing brain function without producing misleading results.
- Results show significant variability in pipeline effectiveness, with many failing to meet key criteria, but a select group of optimal pipelines consistently perform well across various datasets, providing guidance for future research in functional connectomics.
Article Synopsis
- * Results from 200 patients showed significant improvements in hip function and activity levels, with 45% returning to high-impact activities two years post-surgery and no major issues like implant migration or loosening.
- * While the outcomes are positive, further long-term studies are necessary to confirm the effectiveness and safety of this new HRA method.