Publications by authors named "A R Huppler"
Of 319 children with invasive candidiasis, 67 (21%) transitioned from intravenous to enteral antifungal therapy. Eight (12%) transitioned back to intravenous antifungal therapy, one due to perceived treatment failure defined by clinical progression or worsening. Global treatment response at study completion was successful in 66 participants who transitioned to enteral therapy.
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- This study aimed to investigate the effects of remdesivir on liver and kidney function in children with COVID-19, particularly focusing on the prevalence of transaminase and creatinine elevations.
- Out of 180 pediatric patients, 58% experienced mild elevations in transaminases, while only 16% had creatinine elevation, which was mostly temporary.
- The findings suggest that remdesivir has a favorable safety profile in children, with most experiencing only mild and transient liver and kidney function changes during treatment.
Pipeline of Novel Antifungals for Invasive Fungal Disease in Transplant Recipients: A Pediatric Perspective.
J Pediatric Infect Dis Soc
February 2024
Article Synopsis
- Invasive fungal disease (IFD) presents a serious health risk for children who have undergone transplantation, contributing to high rates of illness and death.
- The review highlights new antifungal medications that have been recently approved or are in advanced testing stages, focusing on their mechanisms of action, effectiveness, and specific information for pediatric patients.
- It also examines the important characteristics of these new drugs and their potential future applications in treating pediatric transplant recipients.
Importance: Live vaccines (measles-mumps-rubella [MMR] and varicella-zoster virus [VZV]) have not been recommended after solid organ transplant due to concern for inciting vaccine strain infection in an immunocompromised host. However, the rates of measles, mumps, and varicella are rising nationally and internationally, leaving susceptible immunocompromised children at risk for life-threating conditions.
Objective: To determine the safety and immunogenicity of live vaccines in pediatric liver and kidney transplant recipients.
Background: Adjunctive diagnostic studies (aDS) are recommended to identify occult dissemination in patients with candidemia. Patterns of evaluation with aDS across pediatric settings are unknown.
Methods: Candidemia episodes were included in a secondary analysis of a multicenter comparative effectiveness study that prospectively enrolled participants age 120 days to 17 years with invasive candidiasis (predominantly candidemia) from 2014 to 2017.