Effect of Fresh Whole Blood Donation on Human Performance in United States Special Forces.

Background: Fresh whole blood has been the standard of care for the treatment of hypovolemia secondary to blood loss in the Tactical Combat Casualty Care guidelines since 2014. Current recommendations from the Prolonged Field Care Working Group state that the impact on mission performance is not degraded with 1 unit (450mL) of donation. Because there is limited information on combat performance after donation, the purpose of this investigation was to examine the effects of blood donation on simulated battlefield tasks in U.

Structural insights into subunit-dependent functional regulation in epithelial sodium channels.

Epithelial sodium channels (ENaCs) play a crucial role in Na reabsorption in mammals. To date, four subunits have been identified-α, β, γ, and δ-believed to form different heteromeric complexes. Currently, only the structure of the αβγ complex is known.

Zero-Shot Discovery of High-Performance, Low-Cost Organic Battery Materials Using Machine Learning.

Organic electrode materials (OEMs), composed of abundant elements such as carbon, nitrogen, and oxygen, offer sustainable alternatives to conventional electrode materials that depend on finite metal resources. The vast structural diversity of organic compounds provides a virtually unlimited design space; however, exploring this space through Edisonian trial-and-error approaches is costly and time-consuming. In this work, we develop a new framework, SPARKLE, that combines computational chemistry, molecular generation, and machine learning to achieve zero-shot predictions of OEMs that simultaneously balance reward (specific energy), risk (solubility), and cost (synthesizability).