Publications by authors named "A R Guest"
Article Synopsis
- The study investigates the effectiveness of resting-state functional MRI (rs-fMRI) in localizing the seizure onset zone (SOZ) in epilepsy surgery through comparison with other methods like EEG and surgical outcomes.
- Over 9,500 articles were reviewed, leading to 25 that met inclusion criteria, highlighting various comparative modalities, with rs-fMRI showing significant variability in agreement when compared to different methods.
- Results showed that surgical outcomes had better agreement with rs-fMRI than EEG and intracranial EEG, and the study provided meaningful insights into the heterogeneity of SOZ identification using rs-fMRI techniques.
Objectives: Sleep variability levels are unknown in heavy goods vehicle (HGV) drivers yet are associated with adverse health outcomes and reduced driver vigilance when high.
Methods: Two hundred and thirty-three HGV drivers recruited across 25 UK depots provided sleep variability, sleep duration, and sleep efficiency data via wrist-worn accelerometry (GENEActiv) over 8 days. Sleep variability indicators included social jetlag (the difference in midpoint of the sleep window between work and nonworkdays) and intraindividual variability of sleep window onset time, out-of-bed time, and sleep duration.
Physical inactivity and obesity are widely prevalent in Heavy Goods Vehicle (HGV) drivers. We analysed whether obesity classification influenced the effectiveness of a bespoke structured lifestyle intervention ('SHIFT') for HGV drivers. The SHIFT programme was evaluated within a cluster randomised controlled trial, across 25 transport depots in the UK.
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