Publications by authors named "A R G Cortes"
Leucine-rich repeat kinase 2 (LRRK2) inhibition is a promising disease-modifying therapy for LRRK2-associated Parkinson's disease (L2PD) and idiopathic PD (iPD). However, pharmaco-dynamic readouts and progression biomarkers for clinical trials aiming for disease modification are insufficient since no endogenous marker reflecting enhanced kinase activity of the most common LRRK2 G2019S mutation has been reported yet in L2PD patients. Employing phospho-/proteomic analyses we assessed the impact that LRRK2 activating mutations had in peripheral blood mononuclear cells (PBMCs) from a LRRK2 clinical cohort from Spain (n=174).
View Article and Find Full Text PDFGenome-wide association studies (GWASs) have identified tens of thousands of disease associated variants and provided critical insights into developing effective treatments. However, limited sample sizes have hindered the discovery of variants for uncommon and rare diseases. Here, we introduce KGWAS, a novel geometric deep learning method that leverages a massive functional knowledge graph across variants and genes to improve detection power in small-cohort GWASs significantly.
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- - The Col-ACFF is working on a program to reduce early childhood caries (ECC) in four at-risk Colombian municipalities, analyzing data from children aged 1-5 years to identify inequalities related to household income and education.
- - Findings revealed that about one-third of the children had moderate/extensive caries, with significant disparities in caries prevalence linked to lower education levels—children from less educated households were 6.7 times more likely to have initial caries.
- - The study concluded that while factors like daily fluoride toothpaste use and previous dental care visits have a limited impact on ECC disparities, addressing these inequalities requires comprehensive community and individual interventions.
Article Synopsis
- The study analyzed surface samples and short cores from the southwestern Portuguese shelf, focusing on total organic carbon, nitrogen, C/N ratios, and other metrics to understand the origin of organic matter.
- It was found that organic matter consisted of a mix from both terrestrial and marine sources, with perylene and isotopic signatures used to pinpoint key PAH sources in the area.
- A strong correlation between perylene and USEPA-16 PAHs revealed contributions from natural sources and contaminated materials, highlighting the need for effective marine environmental management practices.
The aim of this short communication is to present a technique to rehabilitate severely discolored teeth with computer-aided designed and computer-aided manufactured (CAD-CAM) zirconia crowns. After confirming the absence of periapical lesions and sufficient crown structure, any caries or fractured restorations can be removed and replaced by an interim composite restoration. A shoulder subgingival preparation is performed and scanned with an intraoral scanner to design a CAD-CAM zirconia crown using a monolithic zirconia material.
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