Publications by authors named "A R Fritzberg"
Article Synopsis
- Low-grade gliomas (LGGs) are the most common brain tumors in children, and they require molecular profiling for accurate diagnosis and treatment planning, making liquid biopsy tests crucial for early detection.
- Researchers analyzed cerebrospinal fluid (CSF) and plasma samples from patients with pilocytic astrocytoma using advanced droplet digital PCR techniques to identify tumor-related genetic changes.
- The study found circulating tumor DNA (ctDNA) in 5 out of 13 CSF samples, revealing important genetic variations, although most samples had low levels of cell-free DNA, indicating the need for improved analysis methods in understanding LGGs.
99mTc-interleukin-2 scintigraphy in normal subjects and in patients with autoimmune thyroid diseases: a feasibility study.
Eur J Nucl Med Mol Imaging
December 2008
Purpose: Radiolabelled interleukin-2 is a radiopharmaceutical used for the study of chronic inflammatory processes. (123)I-labelled interleukin-2 has successfully been used in a large number of patients affected by several immune-mediated diseases. (123)I, however, is expensive and not readily available.
View Article and Find Full Text PDFObjective: Pretargeting is the concept that combines optimal delivery of the antibody and rapid capture and elimination of the radioactivity. In this study, we evaluated the potential of antibody pretargeting to enable the tumor-targeting (212)Pb for in vivo generation of (212)Bi for alpha particle radiotherapy.
Methods: The (212)Pb/(212)Bi chelate of DOTA-biotin, as well as their gamma-emitting analogues, (203)Pb and (205)Bi, was prepared and characterized.
Purpose: The therapeutic efficacy of a unique melanoma-targeting peptide conjugated with an in vivo generated alpha-particle-emitting radionuclide was evaluated in the B16/F1 mouse melanoma animal model. alpha-Radiation is densely ionizing, resulting in high concentrations of destructive radicals and irreparable DNA double-strand breaks. This high linear energy transfer overcomes radiation-resistant tumor cells and oxygen effects resulting in potentially high therapeutic indices in tumors such as melanoma.
View Article and Find Full Text PDFPurpose: The use of an alpha emitter for radioimmunotherapy has potential advantages compared with beta emitters. When administered systemically optimal targeting of intact antibodies requires >24 h, therefore limiting the use of short-lived alpha emitters. This study investigated the biodistribution of bismuth-labeled biotin in A431 tumor-bearing mice pretargeted with antibody B3-streptavidin (B3-SA) and examined the therapeutic efficacy of the alpha emitter, (213)Bi-labeled biotin.
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