Publications by authors named "A R Flores Rendon"
Background: Intravenous (IV) steroids are commonly used to treat acute flares of Crohn's disease (CD). However, it is unclear if they are beneficial in the setting of uncomplicated small bowel obstruction (SBO). We sought to examine if IV steroid administration improved short-term outcomes in patients with CD hospitalized for acute, uncomplicated SBO across three New York City hospital systems.
View Article and Find Full Text PDFPurpose: As part of the 100,000 Genomes Project, we set out to assess the potential viability and clinical impact of reporting genetic variants associated with drug-induced toxicity for patients with cancer recruited for whole-genome sequencing (WGS) as part of a genomic medicine service.
Methods: Germline WGS from 76,805 participants was analyzed for pharmacogenetic (PGx) variants in four genes (, , , ) associated with toxicity induced by five drugs used in cancer treatment (capecitabine, fluorouracil, mercaptopurine, thioguanine, irinotecan). Linking genomic data with prescribing and hospital incidence records, a phenome-wide association study (PheWAS) was performed to identify whether phenotypes indicative of adverse drug reactions (ADRs) were enriched in drug-exposed individuals with the relevant PGx variants.
The Papilla Base CTG: A Novel Approach for Interdental Soft Tissue Reconstruction.
Int J Periodontics Restorative Dent
October 2024
Article Synopsis
- Interdental papilla loss due to periodontal disease introduces issues with speaking, function, and appearance, making it a common problem for patients.
- A new surgical method, utilizing the Connective Tissue Graft (CTG) wall technique, has been introduced to improve the volume of interdental papillae, particularly in areas with clinical attachment loss.
- A case study of a 35-year-old woman showed that this technique resulted in significant improvements in papilla aesthetics and complete root coverage after 6 and 12 months, highlighting the potential of this modified approach for treating gingival recessions.
Article Synopsis
- Scientists are collecting a lot of genetic information from many people around the world to help improve medicine and health care for everyone.
- To make the most out of this data, we need to work together and make it easier to share it safely and fairly.
- The article talks about ways to get better at sharing this data, including using new technology and engaging with communities, and suggests 12 important steps we can all take to make this happen.
A panel of 24 international experts met in July 2022 to discuss challenges associated with pertussis detection, monitoring, and vaccination in adults; conclusions from this meeting are presented. There has been a shift in the epidemiology of pertussis toward older children and adults. This shift has been attributed to the waning of infection- or vaccine-induced immunity, newer detection techniques causing detection bias, and possibly the replacement of whole-cell pertussis with acellular vaccines in high-income countries, which may lead to immunity waning more quickly.
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